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Upstream Scientist

Position Type

Industry


Biotechnology

Job State


US - New Jersey

Must have demonstrated ability to design and evaluate experiments; Excellent scientific understanding of biology and engineering principles for mammalian cell culture, assist in medium design/optimization, process development and scale-up. Flexible in executing and responding to changes in scheduling, along with innovating solutions in a transparent team environment; must have strong focus on creativity and continuous improvement.

Candidate Qualifications:

The company is seeking an individual with the following qualifications and who is willing to make a long-term commitment to the organization:
  • MS/PhD Biology, Biotechnology, Chemical Engineering or equivalent field.
  • PhD with 5+ years of experience or a MS with 8+ years in of experience.
  • Plan and execute experiments to evaluate cell lines, culture media, feeding strategies and process conditions to produce high titer and product quality in support of the expanding Biosimilar pipeline
  • Support experimentation for robust and optimized cell culture manufacturing processes that are developed for mammalian cell lines that has the potential to go into cGMP Manufacturing
  • Knowledge of mammalian cell culture primary recovery a plus.
  • Work in collaboration with Operations group to execute protocols, experimental plans, critical production batches, and tech transfers.
  • Use designed experiments (DOE) to predict/understand/control the impact of process parameters on product quality (CQAs) and production.
  • Represent functional area in team meetings as required
  • Author experimental plans, reports, and operating procedures
  • Maintain a current laboratory notebook with scientific rigor to meet project needs for process development preparation.
  • Work closely with the cell line development team to guide efforts toward clone selection determination.
  • Develop effective mammalian scale-down capabilities and implement effective and scalable process control strategies.
  • Author and support execution of Process Characterization protocols and reports.
  • Assist in optimizing late stage processes already in place to improve product yield.
  • Communicate effectively and follow detailed written and verbal instruction; ability to clearly communicate with others groups and clients as necessary
  • Good conceptual, problem solving, and organizational skills must be detail-oriented, well organized, and able to work independently and in teams.
  • A hands-on energetic individual who enjoys challenges, a quick pace, and is capable and dedicated to getting the job done.
  • An assertive, take-charge, scientist or engineer with a strong results orientation, positive can do attitude, and a sense of urgency to get things done; however with the ability to listen to, learn about, and build upon organizational best practices and successes.
  • A competent, fast learning individual with the ability to multitask and adapt to change.
  • A mature thinking and acting scientist or engineer with good common sense and judgment.
  • Education/Certification
M.S/PhD in Chemical Engineering, Biotechnology or Life Sciences or equivalent field
  • Qualifications and Skills
  • Minimum 5+ years of experience with PhD, 8+ years if MS.
  • Have a working knowledge of cell culture.
  • Demonstrated ability medium and buffer/solution preparation.
  • Demonstrated ability in filtration principles and practice including general operation as well as capacity determination.
  • The applicant should have a working knowledge of the progression of micro scale cell culture development through confirmation of process at pilot scale.
  • The applicant should have a working knowledge of depth filtration.
  • Excellent communication skills, both verbal and written, and the ability to interface effectively with analytical, process, and business development is required.
  • Due to international nature of the tasks, fluency in written and spoken English.
  • Good conceptual, analytical, problem solving, and organizational skills must be detail-oriented, well organized, and able to work independently and in teams.
  • A hands-on energetic individual who enjoys challenges, a quick pace, and is capable and dedicated to getting the job done.
  • An assertive, take-charge, scientist or engineer with a strong results orientation, positive can do attitude, and a sense of urgency to get things done; however with the ability to listen to, learn about, and build upon organizational best practices and successes.
  • A competent, fast learning individual with the ability to multitask and adapt to change.
  • A mature thinking and acting scientist or engineer with good common sense, judgment and decision making skills.


Associated topics: bioengineering, bioinformatic, biomaterials, biomedical, biomedical engineer, bioprocess, hereditary, neuroscience, nutrition, pain

* The salary listed in the header is an estimate based on salary data for similar jobs in the same area. Salary or compensation data found in the job description is accurate.

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